Pathways
ABC Transporters in Cholestatic Hepatocytes
Description:
A cell must selectively translocate molecules across its plasma membrane to maintain the chemical composition of its cytoplasm distinct from that of the surrounding milieu. The most intriguing and, arguably, the most important membrane proteins for this purpose are the ABC (ATP-Binding Cassette) transporters. These proteins, found in all species, use the energy of ATP hydrolysis to translocate specific substrates across cellular membranes. The chemical nature of the substrates handled by ABC transporters is extremely diverse--fr...
References:
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Structure and mechanism of ABC transporters.
F1000Prime Rep. 2015 Feb 3;7:14. doi: 10.12703/P7-14. eCollection 2015. Review. -
Recent advances in the exploration of the bile salt export pump (BSEP/ABCB11) function.
Expert Opin Ther Targets. 2016;20(4):501-14. doi: 10.1517/14728222.2016.1102889. Epub 2015 Nov 17. Review. -
Molecular mechanisms for biliary phospholipid and drug efflux mediated by ABCB4 and bile salts.
Biomed Res Int. 2014;2014:954781. doi: 10.1155/2014/954781. Epub 2014 Jul 15. Review. -
Bile acid transporters and regulatory nuclear receptors in the liver and beyond.
J Hepatol. 2013 Jan;58(1):155-68. doi: 10.1016/j.jhep.2012.08.002. Epub 2012 Aug 8. Review.
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