Pathways
ABCG and ABCA Regulation of Sterol Metabolism
Description:
ATP Binding Cassette transporters comprise a large family of membrane-spanning proteins that are responsible for transporting a variety of substrates in prokaryotes and eukaryotes. The most intriguing and, arguably, the most important membrane proteins for this purpose are the ABC (ATP-Binding Cassette) transporters. These proteins, found in all species, use the energy of ATP hydrolysis to translocate specific substrates across cellular membranes. Many of these transporters are responsible for the translocation of lipophilic sub...
References:
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Structure and mechanism of ABC transporters.
F1000Prime Rep. 2015 Feb 3;7:14. doi: 10.12703/P7-14. eCollection 2015. Review. -
Tracing the structural evolution of eukaryotic ATP binding cassette transporter superfamily.
Sci Rep. 2015 Nov 18;5:16724. doi: 10.1038/srep16724. -
ABCG5/ABCG8 in cholesterol excretion and atherosclerosis.
Clin Chim Acta. 2014 Jan 20;428:82-8. doi: 10.1016/j.cca.2013.11.010. Epub 2013 Nov 16. Review. -
ABCA1 (ATP-Binding Cassette Transporter A1) Mediates ApoA-I (Apolipoprotein A-I) and ApoA-I Mimetic Peptide Mobilization of Extracellular Cholesterol Microdomains Deposited by Macrophages.
Arterioscler Thromb Vasc Biol. 2016 Dec;36(12):2283-2291. Epub 2016 Oct 6.
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