Pathways
Actin Nucleation and Branching
Description:
The actin family is a diverse and evolutionarily ancient group of proteins that provide the supportive framework to the three-dimensional structure of eukaryotic cells. It provides the forces that enable the cell to adopt a variety of shapes and to undertake directed movements. Certain cell types, such as polymorphonuclear leukocytes, monocyte/macrophages, and metastatic cells, are able to move rapidly through tissues and these movements are mediated by the actin cytoskeleton (Ref.1). An important property of actin is its abilit...
References:
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Origin and evolution of the self-organizing cytoskeleton in the network of eukaryotic organelles.
Cold Spring Harb Perspect Biol. 2014 Sep 2;6(9):a016030. doi: 10.1101/cshperspect.a016030. Review. -
Dynamic regulation of sarcomeric actin filaments in striated muscle.
Cytoskeleton (Hoboken). 2010 Nov;67(11):677-92. doi: 10.1002/cm.20476. Review. -
Arp2/3 complex and cofilin modulate binding of tropomyosin to branched actin networks.
Curr Biol. 2015 Jun 15;25(12):1573-82. doi: 10.1016/j.cub.2015.04.038. Epub 2015 May 28. -
A conformational change within the WAVE2 complex regulates its degradation following cellular activation.
Sci Rep. 2017 Mar 23;7:44863. doi: 10.1038/srep44863.
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