Pathways
Actin Nucleation by ARP-WASP Complex
Description:
Actin Nucleation By ARP-WASP Complex For many cell types, the ability to move across a solid surface is fundamental to their biological function. Certain aspects of cell locomotion, such as the protrusion of the plasma membrane in lamellipodia and filopodia, are driven by the polymerization of actin cytoskeleton. The actin cytoskeleton is a dynamic filament network that is essential for cell movement during embryo development, polarization, morphogenesis, cell division, and immune system function and in the metastasis of cancer ...
References:
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Cortactin: a multifunctional regulator of cellular invasiveness.
Cell Adh Migr. 2011 Mar-Apr;5(2):187-98. Epub 2011 Mar 1. Review. -
Under lock and key: spatiotemporal regulation of WASP family proteins coordinates separate dynamic cellular processes.
Semin Cell Dev Biol. 2013 Apr;24(4):258-66. doi: 10.1016/j.semcdb.2012.12.005. Epub 2013 Jan 3. Review. -
Role of the WASP and WAVE family proteins in breast cancer invasion and metastasis.
Breast Cancer (Dove Med Press). 2015 Apr 24;7:99-109. doi: 10.2147/BCTT.S59006. eCollection 2015. Review. -
Structure and role of WASP and WAVE in Rho GTPase signalling in cancer.
Cancer Genomics Proteomics. 2014 May-Jun;11(3):155-65. Review.
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