Pathways
Activation of cAMP-Dependent PKA
Description:
cAMP (Cyclic 3', 5'-Adenosine Monophosphate)-dependent Protein Kinase, commonly known as PKA (Protein Kinase-A), is a second messenger-dependent enzyme that has been implicated in a wide range of cellular processes, including transcription, metabolism, cell cycle progression and apoptosis. Known modulators of PKA activity include factors that either activate or inhibit AC (Adenylate Cyclase), resulting in an increase or decrease in cAMP levels. The enzyme occurs naturally as a four-membered structure with two regulatory (R) and ...
References:
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Targeting protein kinase A in cancer therapy: an update.
EXCLI J. 2014 Aug 18;13:843-55. eCollection 2014. Review. -
Evolutionary paths of the cAMP-dependent protein kinase (PKA) catalytic subunits.
PLoS One. 2013 Apr 12;8(4):e60935. doi: 10.1371/journal.pone.0060935. Print 2013. -
G protein-dependent and G protein-independent signaling pathways and their impact on cardiac function.
Circ Res. 2011 Jul 8;109(2):217-30. doi: 10.1161/CIRCRESAHA.110.231225. Review. -
Cyclic AMP dynamics in the pancreatic β-cell.
Ups J Med Sci. 2012 Nov;117(4):355-69. doi: 10.3109/03009734.2012.724732. Epub 2012 Sep 13. Review.
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