Activation of NF-KappaB by PKR

Description:

PKR (Protein Kinase-R) is a 68-kDa serine–threonine kinase that appears to play a primary role in mediating the antiviral activities of infected cells. PKR mediates apoptosis induced by many different stimuli, such as LPS (Lipopolysaccharides), TNF-Alpha (Tumour Necrosis Factor-Alpha), viral infection, or serum starvation. Viral infection leads to the increased expression and secretion of the cytokine IFN-Gamma (Interferon- Gamma) from host cells. IFN-gamma induces the dsRNA (Double-Stranded RNA)-dependent PKR. dsRNA, produced...

References:

Double-stranded RNA-dependent protein kinase deficiency protects the heart from systolic overload-induced congestive heartfailure.
Wang H, Xu X, Fassett J, Kwak D, Liu X, Hu X, Falls TJ, Bell JC, Li H, Bitterman P, Bache RJ, Chen Y.
Circulation. 2014 Apr 1;129(13):1397-406. doi: 10.1161/CIRCULATIONAHA.113.002209. Epub 2014 Jan 24.
Stimulators of translation identified during a small molecule screening campaign.
Shin U, Williams DE, Kozakov D, Hall DR, Beglov D, Vajda S, Andersen RJ, Pelletier J.
Anal Biochem. 2014 Feb 15;447:6-14.
Double stranded RNA-dependent protein kinase promotes the tumorigenic phenotype in HepG2 hepatocellular carcinomacells by activating STAT3.
Wang X, Dong JH, Zhang WZ, Leng JJ, Cai SW, Chen MY, Yang X.
Oncol Lett. 2014 Dec;8(6):2762-2768. Epub 2014 Sep 24.
dsRNA-dependent protein kinase PKR and its role in stress, signaling and HCV infection.
Dabo S, Meurs EF.
Viruses. 2012 Oct 29;4(11):2598-635. doi: 10.3390/v4112598. Review.

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Pathways

Activation of NF-KappaB by PKR

Description:

References:

Double-stranded RNA-dependent protein kinase deficiency protects the heart from systolic overload-induced congestive heartfailure.

Stimulators of translation identified during a small molecule screening campaign.

Double stranded RNA-dependent protein kinase promotes the tumorigenic phenotype in HepG2 hepatocellular carcinomacells by activating STAT3.

dsRNA-dependent protein kinase PKR and its role in stress, signaling and HCV infection.

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Pathways

Activation of NF-KappaB by PKR

Description:

References:

Double-stranded RNA-dependent protein kinase deficiency protects the heart from systolic overload-induced congestive heartfailure.

Stimulators of translation identified during a small molecule screening campaign.

Double stranded RNA-dependent protein kinase promotes the tumorigenic phenotype in HepG2 hepatocellular carcinomacells by activating STAT3.

dsRNA-dependent protein kinase PKR and its role in stress, signaling and HCV infection.

Databases

Tools

Institutional License

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