Pathways
Activation of PKA through GPCR
Description:
PKA (Protein Kinase-A) is a second messenger-dependent enzyme that has been implicated in a wide range of cellular processes, including transcription, metabolism, cell cycle progression and apoptosis. Known modulators of PKA activity include factors that either activate or inhibit AC (Adenylate Cyclase), resulting in an increase or decrease in cAMP (Cyclic Adenosine 3',5'-monophosphate) levels. The enzyme occurs naturally as a four-membered structure with two regulatory (R) and two catalytic (C) subunits. Four genes encode the R...
References:
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Cyclic AMP Sensor EPAC Proteins and Their Role in Cardiovascular Function and Disease.
Circ Res. 2016 Mar 4;118(5):881-97. doi: 10.1161/CIRCRESAHA.115.306529. Review. -
PKA: lessons learned after twenty years.
Biochim Biophys Acta. 2013 Jul;1834(7):1271-8. doi: 10.1016/j.bbapap.2013.03.007. Epub 2013 Mar 25. Review. -
Pancreatic Beta Cell G-Protein Coupled Receptors and Second Messenger Interactions: A Systems Biology ComputationalAnalysis.
PLoS One. 2016 May 3;11(5):e0152869. doi: 10.1371/journal.pone.0152869. eCollection 2016. -
Minireview: Targeting GPCR Activated ERK Pathways for Drug Discovery.
Curr Chem Genom Transl Med. 2013 Jul 26;7:9-15. doi: 10.2174/2213988501307010009. eCollection 2013.
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