Pathways
Activation of PKC through GPCR
Description:
PKC (Protein Kinase-C) is a cyclic nucleotide-independent enzyme that phosphorylates serine and threonine residues in many target proteins. PKC plays a pivotal role in mediating cellular responses to extracellular stimuli involved in proliferation, differentiation, apoptosis, and exocytotic release in a number of non-neuronal systems such as Islet cells, Chromaffin cells and Paramecium. PKC has also been implicated in phosphorylation of several neuronal proteins, which are thought to regulate neurotransmitter release and establi...
References:
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Protein kinase C: an attractive target for cancer therapy.
Cancers (Basel). 2011 Feb 1;3(1):531-67. doi: 10.3390/cancers3010531. -
Regulation of Ca(V)2 calcium channels by G protein coupled receptors.
Biochim Biophys Acta. 2013 Jul;1828(7):1629-43. doi: 10.1016/j.bbamem.2012.10.004. Epub 2012 Oct 12. Review. -
Protein Kinase C Inhibitors as Modulators of Vascular Function and their Application in Vascular Disease.
Pharmaceuticals (Basel). 2013;6(3):407-39. doi: 10.3390/ph6030407. -
Multifactorial Regulation of G Protein-Coupled Receptor Endocytosis.
Biomol Ther (Seoul). 2017 Jan 1;25(1):26-43. doi: 10.4062/biomolther.2016.186. Review.
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