Pathways
Agrin Interactions at Neuromuscular Junction
Description:
The development of the NMJ (Neuromuscular Junction) is triggered by agrin, a signaling factor that is deposited by the nerve terminal at the site of contact with the muscle cell. Motor neuron-derived agrin induces many aspects of synaptic differentiation and is required for the postsynaptic localization of many synapse-specific basal lamina, transmembrane, and cytoplasmic proteins. In addition, agrin is sufficient to induce aggregation of these synaptic proteins in muscle cells in vitro, or at ectopic sites on muscle fibers i...
References:
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Structural mechanisms of the agrin-LRP4-MUSK signaling pathway in neuromuscular junction differentiation.
Cell Mol Life Sci. 2013 Sep;70(17):3077-88. doi: 10.1007/s00018-012-1209-9. Epub 2012 Nov 22. Review. -
Molecular control of neuromuscular junction development.
J Cachexia Sarcopenia Muscle. 2012 Mar;3(1):13-23. doi: 10.1007/s13539-011-0041-7. Epub 2011 Oct 14. -
The biochemical and mass spectrometric profiling of the dystrophin complexome from skeletal muscle.
Comput Struct Biotechnol J. 2015 Nov 26;14:20-7. doi: 10.1016/j.csbj.2015.11.002. eCollection 2016. Review. -
Can agrin cerebrospinal fluid concentration be used as an early biomarker for Alzheimer's disease?
Alzheimers Dement (Amst). 2015 Mar 29;1(1):75-80. doi: 10.1016/j.dadm.2014.11.008. eCollection 2015 Mar.
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