Pathways
AHR Pathway
Description:
AHR is a cytosolic receptor for low molecular weight molecules, binding and becoming activated by sterically planar ligands approximately three benzene rings in size. It is maximally expressed in interface tissues including the liver, lungs, skin and gastrointestinal tract [Ref.1]. It is recognized as the culprit for most toxic responses observed after exposure to PAH (Polycyclic Aromatic Hydrocarbons), Dioxins (e.g. TCDD (2, 3, 7, 8-tetrachlorodibenzo-p-dioxin)), and PCBs(Polychlorinated Biphenyls),3MC,β-NF and B[a]P. I...
References:
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The aryl hydrocarbon receptor: a review of its role in the physiology and pathology of the integument and its relationship to the tryptophan metabolism.
Int J Tryptophan Res. 2015 Feb 10; 8:7-18. doi: 10.4137/IJTR.S19985. eCollection 2015. Review. -
Ah receptor: dioxin-mediated toxic responses as hints to deregulated physiologic functions.
Biochem Pharmacol. 2006 Aug 14; 72(4):393-404. Epub 2006 Mar 20. Review. -
The Aryl hydrocarbon receptor: an illuminating effector of the UVB response.
Sci STKE. 2007 Sep 11; 2007(403):pe49. -
Agonist and chemopreventative ligands induce differential transcriptional cofactor recruitment by aryl hydrocarbon receptor.
Mol Cell Biol. 2003 Nov; 23(21):7920-5.
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