Pathways
AIF Pathway
Description:
AIF (apoptosis-inducing factor), is a phylogenetically old flavoprotein which is confined to the mitochondrial intermembrane space in healthy cells but upon lethal signaling, it translocates, via the cytosol, to the nucleus where it binds to DNA and provokes Caspase-independent chromatin condensation [Ref.1]. Proteolysis of the membrane tether in mature AIF can be mediated by local or cytoplasmic proteases entering the intermembrane space upon permeabilization of the outer membrane. Mitochondrial membrane permeabilization leads ...
References:
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Apoptosis-inducing factor (AIF): key to the conserved caspase-independent pathways of cell death?
J Cell Sci. 2002 Dec 15; 115(Pt 24):4727-34. -
Apoptosis-inducing factor: structure, function, and redox regulation.
Antioxid Redox Signal. 2011 Jun 15; 14(12):2545-79. doi: 10.1089/ars.2010.3445. Epub 2011 Mar 10. -
Dueling activities of AIF in cell death versus survival: DNA binding and redox activity.
Cell. 2002 Oct 18; 111(2):147-50. -
AIF: a multifunctional cog in the life and death machine.
Sci STKE. 2003 Jul 29; 2003(193):PE31.
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