Pathways
Akt Signaling
Description:
AKT/PKB Pathway is an evolutionarily conserved serine/threonine kinase Pathway involved in a wide variety of cellular functions, including proliferation, cell survival, differentiation, glucose mobilization, homeostasis, cell migration, and apoptosis. Three isoforms, AKT1,AKT2, and AKT3, are expressed in mammals (Ref.1 & 2). Akt is a central node in cell signaling downstream of growth factors, cytokines, and other cellular stimuli. Aberrant loss or gain of Akt activation underlies the pathophysiological properties of a variety ...
References:
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Targeting the AKT protein kinase for cancer chemoprevention.
Mol Cancer Ther. 2007 Aug;6(8):2139-48. Review. -
Ankrd2/ARPP is a novel Akt2 specific substrate and regulates myogenic differentiation upon cellular exposure to H(2)O(2).
Mol Biol Cell. 2011 Aug 15;22(16):2946-56. doi: 10.1091/mbc.E10-11-0928. Epub 2011 Jul 7. -
AKT/PKB signaling: navigating downstream.
Cell. 2007 Jun 29;129(7):1261-74. Review. -
The E3 ligase TRAF6 regulates Akt ubiquitination and activation.
Science. 2009 Aug 28;325(5944):1134-8.
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