Pathways
D-Alanine Metabolism in C. acetobutylicum
Description:
The Clostridia are a diverse group of Gram-positive, rod-shaped anaerobes that include several toxin-producing pathogens (notably Clostridium difficile, Clostridium botulinum, Clostridium tetani, Clostridium acetobutylicum and Clostridium perfringens) and a large number of terrestrial species that produce acetone, butanol, ethanol, isopropanol, and organic acids through fermentation of a variety of carbon sources. C. acetobutylicum strain ATCC 824 has been used for the industrial production of acetone, butanol, and ethanol ...
References:
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Physiology and Sporulation in Clostridium.
Microbiol Spectr. 2014 Aug;2(4):TBS-0010-2012. -
Structural and biochemical analyses of alanine racemase from the multidrug-resistant Clostridium difficile strain 630.
Acta Crystallogr D Biol Crystallogr. 2014 Jul;70(Pt 7):1922-33. -
Selection and characterization of alanine racemase inhibitors against Aeromonas hydrophila.
BMC Microbiol. 2017 May 25;17(1):122. -
Structural evidence that alanine racemase from a D-cycloserine-producing microorganism exhibits resistance to its own product.
J Biol Chem. 2004 Oct 29;279(44):46153-61
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