D-Alanine Metabolism in S. agalactiae 2603

Description:

Streptococcus agalactiae, or Group-B Streptococcus is a Gram-positive nonmotile bacterium and is the leading cause of bacterial sepsis, pneumoniae and meningitidis in neonates in U.S. and Europe. It usually behaves as a commensal organism that colonizes the gastrointestinal or genital tract of 25-40% of healthy women, but it can cause life-threatening invasive infection in susceptible hosts: newborn infants, pregnant women, and adults with underlying chronic illnesses (Ref.1).

As is the case in other Gram-posit...

References:

Determinants of Group B streptococcal virulence potential amongst vaginal clinical isolates from pregnant women.
Burcham LR, Spencer BL, Keeler LR, Runft DL, Patras KA, Neely MN, Doran KS.
PLoS One. 2019 Dec 18;14(12):e0226699. doi: 10.1371/journal.pone.0226699.
Biosynthesis of teichoic acids in Streptococcus pneumoniae and closely related species: lessons from genomes.
Denapaite D, Brückner R, Hakenbeck R, Vollmer W.
Microb Drug Resist. 2012 Jun;18(3):344-58. doi: 10.1089/mdr.2012.0026. Epub 2012 Mar 20.
The crystal structure of alanine racemase from Streptococcus pneumoniae, a target for structure-based drug design.
Im H, Sharpe ML, Strych U, Davlieva M, Krause KL.
BMC Microbiol. 2011 May 25;11:116. doi: 10.1186/1471-2180-11-116.
Revised mechanism of D-alanine incorporation into cell wall polymers in Gram-positive bacteria.
Reichmann NT, Cassona CP, Gründling A.
Microbiology (Reading). 2013 Sep;159(Pt 9):1868-1877. doi: 10.1099/mic.0.069898-0. Epub 2013 Jul 15.

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D-Alanine Metabolism in S. agalactiae 2603

Description:

References:

Determinants of Group B streptococcal virulence potential amongst vaginal clinical isolates from pregnant women.

Biosynthesis of teichoic acids in Streptococcus pneumoniae and closely related species: lessons from genomes.

The crystal structure of alanine racemase from Streptococcus pneumoniae, a target for structure-based drug design.

Revised mechanism of D-alanine incorporation into cell wall polymers in Gram-positive bacteria.

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Tools

Institutional License

Pathways

D-Alanine Metabolism in S. agalactiae 2603

Description:

References:

Determinants of Group B streptococcal virulence potential amongst vaginal clinical isolates from pregnant women.

Biosynthesis of teichoic acids in Streptococcus pneumoniae and closely related species: lessons from genomes.

The crystal structure of alanine racemase from Streptococcus pneumoniae, a target for structure-based drug design.

Revised mechanism of D-alanine incorporation into cell wall polymers in Gram-positive bacteria.

Databases

Tools

Institutional License

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