Pathways
D-Alanine Metabolism in S. agalactiae NEM316
Description:
Streptococcus agalactiae, or Group-B Streptococcus is a Gram-positive nonmotile bacterium and is the leading cause of bacterial sepsis, pneumoniae and meningitidis in neonates in U.S. and Europe. It usually behaves as a commensal organism that colonizes the gastrointestinal or genital tract of 25-40% of healthy women, but it can cause life-threatening invasive infection in susceptible hosts: newborn infants, pregnant women, and adults with underlying chronic illnesses. First recognized as a pathogen in bovine mastiti...
References:
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Understanding the regulation of Group B Streptococcal virulence factors.genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae.
Future Microbiol. 2009 Mar;4(2):201-21. doi: 10.2217/17460913.4.2.201. -
Role of the Group B antigen of Streptococcus agalactiae: a peptidoglycan-anchored polysaccharide involved in cell wall biogenesis.
PLoS Pathog. 2012;8(6):e1002756. doi: 10.1371/journal.ppat.1002756. Epub 2012 Jun 14. -
Revised mechanism of D-alanine incorporation into cell wall polymers in Gram-positive bacteria.
Microbiology (Reading). 2013 Sep;159(Pt 9):1868-1877. doi: 10.1099/mic.0.069898-0. Epub 2013 Jul 15. -
Purification, Characterization and Inhibition of Alanine Racemase from a Pathogenic Strain of Streptococcus iniae.
Pol J Microbiol. 2019 Sep;68(3):331-341. doi: 10.33073/pjm-2019-036. Epub 2019 Sep 3.
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