Pathways
D-Alanine Metabolism in S. aureus COL
Description:
Staphylococcus aureus are Gram-positive nonmotile coccus that grows in aerobic and anaerobic conditions, in which it forms grape-like clusters. S. aureus is an opportunistic pathogen and the major causative agent of numerous hospital- and community-acquired infections. It produces numerous toxins including super antigens that cause unique disease entities such as toxic-shock syndrome and staphylococcal scarlet fever. Its genetic plasticity has facilitated the evolution of many virulent and drug-resistant str...
References:
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Staphylococcal scarlet fever associated with staphylococcal enterotoxin M in an elderly patient.
Int J Infect Dis. 2019 Aug;85:7-9. doi: 10.1016/j.ijid.2019.05.012. Epub 2019 May 13. -
Lipoteichoic Acid Biosynthesis Inhibitors as Potent Inhibitors of S. aureus and E. faecalis Growth and Biofilm Formation.
Molecules. 2020 May 12;25(10):2277. doi: 10.3390/molecules25102277. -
Thiadiazolidinones: a new class of alanine racemase inhibitors with antimicrobial activity against methicillin-resistant Staphylococcus aureus.
Biochem Pharmacol. 2012 Feb 1;83(3):368-77. doi: 10.1016/j.bcp.2011.11.021. Epub 2011 Nov 29. -
An integrated computational and experimental study to investigate Staphylococcus aureus metabolism.
NPJ Syst Biol Appl. 2020 Jan 30;6(1):3. doi: 10.1038/s41540-019-0122-3.
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