Pathways
D-Alanine Metabolism in S. aureus Mu50
Description:
Staphylococcus aureus are facultative anaerobic Gram-positive cocci, that is a major cause of hospital acquired (nosocomial) infection of surgical wounds and infections associated with indwelling medical devices. S. aureus causes food poisoning by releasing enterotoxins into food, and toxic shock syndrome by release of superantigens into the blood stream. Over the last decade, VRSA (Vancomycin Resistant S. aureus) strains have become endemic in hospitals worldwide. The VRSA phenotype of S. aureu...
References:
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Complete Reconstitution of the Vancomycin-Intermediate Staphylococcus aureus Phenotype of Strain Mu50 in Vancomycin-Susceptible S. aureus.
Antimicrob Agents Chemother. 2016 May 23;60(6):3730-42. doi: 10.1128/AAC.00420-16. -
Analysis of Cell Wall Teichoic Acids in Staphylococcus aureus.
Methods Mol Biol. 2016;1440:201-13. doi: 10.1007/978-1-4939-3676-2_15. -
Structural features and kinetic characterization of alanine racemase from Staphylococcus aureus (Mu50).
Acta Crystallogr D Biol Crystallogr. 2012 Jan;68(Pt 1):82-92. doi: 10.1107/S0907444911050682. Epub 2011 Dec 9. -
A D-Alanine auxotrophic live vaccine is effective against lethal infection caused by Staphylococcus aureus.
Virulence. 2018 Jan 1;9(1):604-620. doi: 10.1080/21505594.2017.1417723.
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