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D-Alanine Metabolism in S. aureus MW2
Description:
Staphylococcus aureus are Gram-positive nonmotile coccus that grows in aerobic and anaerobic conditions, in which it forms grape-like clusters. S. aureus is one of the major causes of community-acquired and hospital-acquired infections. It produces numerous toxins including superantigens that cause unique disease entities such as toxic-shock syndrome and staphylococcal scarlet fever. S. aureus MW2 is a typical community-acquired strain of MRSA (Methicillin-Resistant S. aureus) isolated in 1...
References:
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Diverse virulence of Staphylococcus aureus strains for the conjunctiva.
Curr Eye Res. 2011 Jan;36(1):14-20. doi: 10.3109/02713683.2010.523194. -
Peptidoglycan and Teichoic Acid Levels and Alterations in Staphylococcus aureus by Cell-Wall and Whole-Cell Nuclear Magnetic Resonance.
Biochemistry. 2018 Jul 3;57(26):3966-3975. doi: 10.1021/acs.biochem.8b00495. Epub 2018 Jun 11. -
A D-Alanine auxotrophic live vaccine is effective against lethal infection caused by Staphylococcus aureus.
Virulence. 2018 Jan 1;9(1):604-620. doi: 10.1080/21505594.2017.1417723. -
Mechanisms of vancomycin resistance in Staphylococcus aureus.
J Clin Invest. 2014 Jul;124(7):2836-40. doi: 10.1172/JCI68834. Epub 2014 Jul 1.
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