Pathways
D-Alanine Metabolism in B. bronchiseptica
Description:
Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica are closely related Gram-negative Beta-proteobacteria that colonizes the respiratory tracts of mammals. B. bronchiseptica causes chronic respiratory infections in a wide range of animals. D-Alanine is a necessary precursor in the biosynthesis of cell wall in this bacterium (Ref.1).
The naturally occurring L-Alanine isomer is racemized to its D-form through the action of a class of enzymes called alr
You can view details of this pathway by subscribing:References:
Peptidoglycan Muropeptides: Release, Perception, and Functions as Signaling Molecules.
Front Microbiol. 2019 Mar 28;10:500. doi: 10.3389/fmicb.2019.00500.
Racemization in reverse: evidence that D-amino acid toxicity on Earth is controlled by bacteria with racemases.
PLoS One. 2014 Mar 19;9(3):e92101. doi: 10.1371/journal.pone.0092101.
Probing alanine transaminase catalysis with hyperpolarized 13CD3-pyruvate.
J Magn Reson. 2013 Mar;228:59-65. doi: 10.1016/j.jmr.2012.12.013. Epub 2013 Jan 4.
d-Alanine metabolism is essential for growth and biofilm formation of Streptococcus mutans.
Mol Oral Microbiol. 2016 Oct;31(5):435-44. doi: 10.1111/omi.12146. Epub 2015 Dec 2.
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