Pathways
D-Alanine Metabolism in C. crescentus
Description:
Caulobacter crescentus is a Gram-negative non-pathogenic bacterium that grows in dilute aquatic environments. It is a member of the Alpha-subdivision of Proteobacteria. C. crescentus invariably differentiates and divides asymmetrically at each cell cycle. C. crescentus is a simple and highly manipulable single-celled model system to study cellular differentiation, asymmetric division, and their coordination with Cell Cycle progression (Ref.1). The cell wall of this bacterium is a unique biopolymer, containing both ...
References:
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Both clinical and environmental Caulobacter species are virulent in the Galleria mellonella infection model.
PLoS One. 2020 Mar 12;15(3):e0230006. -
Structural and biochemical analyses of alanine racemase from the multidrug-resistant Clostridium difficile strain 630.
Acta Crystallogr D Biol Crystallogr. 2014 Jul;70(Pt 7):1922-33. -
Inhibitors of alanine racemase enzyme: a review.
J Enzyme Inhib Med Chem. 2016 Aug;31(4):517-26. -
Molecular dynamics studies of alanine racemase: a structural model for drug design.
Biopolymers 2003 Oct;70(2):186-200
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