Pathways
D-Alanine Metabolism in L. innocua
Description:
The bacterial genus Listeria is currently taxonomically subdivided into six species: L. monocytogenes, L. seeligeri, L. ivanovii, L. innocua, L. grayi, and L. welshimeri. Two of the species are pathogenic, causing the disease listeriosis. L. innocua is widespread in the environment and in food. The only phenotypic characteristic that classically distinguishes L. monocytogenes from L. innocua is hemolysis (Ref.1).
As in most Gram-positive bacteria, the cell wall of L. monocytogenes is ...
References:
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Characteristics and distribution of Listeria spp., including Listeria species newly described since 2009.
Appl Microbiol Biotechnol. 2016 Jun;100(12):5273-87. doi: 10.1007/s00253-016-7552-2. Epub 2016 Apr 29. -
Discovery of genes required for lipoteichoic acid glycosylation predicts two distinct mechanisms for wall teichoic acid glycosylation.
J Biol Chem. 2018 Mar 2;293(9):3293-3306. doi: 10.1074/jbc.RA117.001614. Epub 2018 Jan 17. -
A D-Alanine auxotrophic live vaccine is effective against lethal infection caused by Staphylococcus aureus.
Virulence. 2018 Jan 1;9(1):604-620. doi: 10.1080/21505594.2017.1417723. -
Structure of the Mycobacterium tuberculosis D-alanine:D-alanine ligase, a target of the antituberculosis drug D-cycloserine.
Antimicrob Agents Chemother. 2011 Jan;55(1):291-301. doi: 10.1128/AAC.00558-10. Epub 2010 Oct 18.
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