Pathways
D-Alanine Metabolism in L. johnsonii
Description:
Lactic acid bacteria play important roles in food conservation because of their fermentative ability and contribute to the equilibrium of the gastrointestinal tract microbiota. Lactobacillus johnsonii (L. johnsonii) is commonly found in the gastrointestinal tract and adhere to intestinal cells. Such interactions of bacteria with the gastrointestinal tract contribute to its protection against pathogenic microorganisms. A close association between the bacteria and their environment undoubtedly results in adaptati...
References:
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Lactobacillus johnsonii ameliorates intestinal, extra-intestinal and systemic pro-inflammatory immune responses following murine Campylobacter jejuni infection.
Sci Rep. 2017 May 18;7(1):2138. doi: 10.1038/s41598-017-02436-2. -
L-alanine auxotrophy of Lactobacillus johnsonii as demonstrated by physiological, genomic, and gene complementation approaches.
Appl Environ Microbiol. 2004 Mar;70(3):1869-73. doi: 10.1128/aem.70.3.1869-1873.2004. -
d-Alanyl-d-Alanine Ligase as a Broad-Host-Range Counterselection Marker in Vancomycin-Resistant Lactic Acid Bacteria.
J Bacteriol. 2018 Jun 11;200(13):e00607-17. doi: 10.1128/JB.00607-17. -
A partial reconstitution implicates DltD in catalyzing lipoteichoic acid d-alanylation.
J Biol Chem. 2018 Nov 16;293(46):17985-17996. doi: 10.1074/jbc.RA118.004561. Epub 2018 Sep 20.
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