Pathways
D-Alanine Metabolism in G. kaustophilus
Description:
Geobacillus kaustophilus HTA426, which was isolated from the deep-sea sediment of the Mariana Trench, is a thermophilic Bacillus-related species whose upper temperature limit for growth is 74 degrees Celsius (optimally 60 degrees Celsius). It is known that there are at least 12 other thermophilic Geobacillus species, which have been reclassified from the genus Bacillus (Ref.1).The cell wall of these bacteria is a unique biopolymer, containing both D- and L-Amino acids. The terminal peptide is D-Alanine although other...
References:
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Isolation and complete genome sequence of the thermophilic Geobacillus sp. 12AMOR1 from an Arctic deep-sea hydrothermal vent site.
Stand Genomic Sci. 2016 Feb 24;11:16. doi: 10.1186/s40793-016-0137-y. -
Revised mechanism of D-alanine incorporation into cell wall polymers in Gram-positive bacteria.
Microbiology (Reading). 2013 Sep;159(Pt 9):1868-1877. doi: 10.1099/mic.0.069898-0. Epub 2013 Jul 15. -
Inhibitors of alanine racemase enzyme: a review.
J Enzyme Inhib Med Chem. 2016 Aug;31(4):517-26. doi: 10.3109/14756366.2015.1050010. Epub 2015 May 29. Erratum in: J Enzyme Inhib Med Chem. 2018 Dec;33(1):726. -
Functional and structural characterization of thermostable D-amino acid aminotransferases from Geobacillus spp.
Appl Environ Microbiol. 2006 Feb;72(2):1588-94. doi: 10.1128/AEM.72.2.1588-1594.2006.
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