Pathways
D-Alanine Metabolism in B. melitensis
Description:
Brucella is a Gram-negative aerobic pathogen that is distringuished from most other pathogens because it does not have "obvious virulence factors" like capsules, fimbriae, flagella, exotoxins, exproteases, or other exoenzymes, cytolysins, resistance forms, antigenic variation, plamids, or lysogenic phages. Brucella sp. causes a "zoonotic disease endemic in many areas of the world, characterized by chronic infections in animals leading to abortion and infertility, and a systemic, febrile illnes...
References:
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Neurological Manifestations of Brucellosis in an Indian Population.
Cureus. 2016 Jul 12;8(7):e684. doi: 10.7759/cureus.684. -
Immunomodulatory properties of Brucella melitensis lipopolysaccharide determinants on mouse dendritic cells in vitro and in vivo.
Virulence. 2018 Jan 1;9(1):465-479. doi: 10.1080/21505594.2017.1386831. -
From the regulation of peptidoglycan synthesis to bacterial growth and morphology.
Nat Rev Microbiol. 2011 Dec 28;10(2):123-36. doi: 10.1038/nrmicro2677. -
PhiA, a Peptidoglycan Hydrolase Inhibitor of Brucella Involved in the Virulence Process.
Infect Immun. 2019 Jul 23;87(8):e00352-19. doi: 10.1128/IAI.00352-19.
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