Pathways
D-Alanine Metabolism in L. monocytogenes EGD-e
Description:
Listeria monocytogenes(L. monocytogenes) is a Gram-positive facultative intracellular bacterial pathogen that elicits a strong cellular immune response following infection and therefore has potential use as a vaccine vector. However, while infections by L. monocytogenes are fairly rare and can readily be controlled by a number of antibiotics, the organism can nevertheless cause meningitis and death, particularly in immunocompromised or pregnant patients. L. monocytogenes EGD-e (Serovar 1/2a) is a de...
References:
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Metabolism of the Gram-Positive Bacterial Pathogen Listeria monocytogenes.
Microbiol Spectr. 2019 Jul;7(4):10.1128/microbiolspec.GPP3-0066-2019. doi: 10.1128/microbiolspec.GPP3-0066-2019. -
Structure and function of Listeria teichoic acids and their implications.
Mol Microbiol. 2020 Mar;113(3):627-637. doi: 10.1111/mmi.14472. -
A D-Alanine auxotrophic live vaccine is effective against lethal infection caused by Staphylococcus aureus.
Virulence. 2018 Jan 1;9(1):604-620. doi: 10.1080/21505594.2017.1417723. -
Analysis of carbon substrates used by Listeria monocytogenes during growth in J774A.1 macrophages suggests a bipartite intracellular metabolism.
Front Cell Infect Microbiol. 2014 Nov 3;4:156. doi: 10.3389/fcimb.2014.00156.
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