Pathways
D-Alanine Metabolism in S. mutans
Description:
Based on differences in their compositions and the linkages of cell wall polysaccharides, Streptococci are classified into eight serotypes as follows; Streptococcus mutans (Serotypes c, e, and f), Streptococcus sobrinus (Serotypes d and g), Streptococcus cricetus (Serotype a), Streptococcus rattus (Serotype b), Streptococcus ferus (Serotype c), Streptococcus macacae (Serotype c), and Streptococcus downei (Serotype h). Among these, S. mutans is known to be...
References:
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Contribution of Severe Dental Caries Induced by Streptococcus mutans to the Pathogenicity of Infective Endocarditis.
Infect Immun. 2020 Jun 22;88(7):e00897-19. doi: 10.1128/IAI.00897-19. -
D-alanylation of lipoteichoic acids confers resistance to cationic peptides in group B streptococcus by increasing the cell wall density.
PLoS Pathog . 2012 Sep;8(9):e1002891. doi: 10.1371/journal.ppat.1002891. Epub 2012 Sep 6. -
d-Alanine metabolism is essential for growth and biofilm formation of Streptococcus mutans.
Mol Oral Microbiol. 2016 Oct;31(5):435-44. doi: 10.1111/omi.12146. Epub 2015 Dec 2. -
Systematic approach to optimizing specifically targeted antimicrobial peptides against Streptococcus mutans.
Antimicrob Agents Chemother. 2010 May;54(5):2143-51. doi: 10.1128/AAC.01391-09. Epub 2010 Mar 8.
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