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Pathways

D-Alanine Metabolism in B. pertussis

Description:

Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica are closely related Gram-negative Beta-proteobacteria that colonizes the respiratory tracts of mammals. B. pertussis is a strict human pathogen of recent evolutionary origin and is the primary etiologic agent of whooping cough. D-Alanine is a necessary precursor in the biosynthesis of cell wall in this bacterium (Ref.1).
 
The naturally occurring L-Alanine isomer is racemized to its D-form through the action of a class of e...

References:

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