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D-Alanine Metabolism in L. pneumophila Lens


Legionella pneumophila is the causative agent of Legionnaires' disease, which replicates as an intracellular parasite of amoebae and persists in the environment as a free-living microbe (Ref.1 & 2). D-Alanine is a necessary precursor in the biosynthesis of cell wall in this bacterium. The naturally occurring L-Alanine isomer is racemized to its D-form through the action of a class of enzymes called AlRs (Alanine Racem[...]




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