Pathways
D-Alanine Metabolism in L. pneumophila Lens
Description:
Legionella pneumophila is the causative agent of Legionnaires' disease, which replicates as an intracellular parasite of amoebae and persists in the environment as a free-living microbe (Ref.1). D-Alanine is a necessary precursor in the biosynthesis of cell wall in this bacterium. L-Alanine is also a product of several other metabolic pathways like Cyanoamino Acid Metabolism, Selenoamino Acid Metabolism, Alanine and Aspartate, and D-Arginine and D-Ornithine Metabolism(Ref.2). The naturally occurring L-Alanine isomer is ra...
References:
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Molecular pathogenesis of infections caused by Legionella pneumophila.
Clin Microbiol Rev. 2010 Apr;23(2):274-98. doi: 10.1128/CMR.00052-09. -
Illumination of growth, division and secretion by metabolic labeling of the bacterial cell surface.
FEMS Microbiol Rev. 2015 Mar;39(2):184-202. doi: 10.1093/femsre/fuu012. Epub 2015 Jan 23. -
Alanine racemase mutants of Burkholderia pseudomallei and Burkholderia mallei and use of alanine racemase as a non-antibiotic-based selectable marker.
PLoS One. 2011;6(6):e21523. doi: 10.1371/journal.pone.0021523. Epub 2011 Jun 24. -
Metabolism of Legionella pneumophila Hosted by Acanthamoeba castellanii.
Biopolymers 2003 Oct; 70(2):186-200
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