Pathways
D-Alanine Metabolism in S. pyogenes SF370
Description:
The Group-A Streptococcus (Streptococcus pyogenes) remains an important human pathogen, associated with a range of superficial skin and throat infections as well as a variety of more serious invasive infections and autoimmune sequelae such as acute rheumatic fever and post-streptococcal glomerulonephritis (Ref.1). S. pyogenes strains are grouped into two classes on the basis of post infectious sequelae associated with each strain, Class-I is responsible for rheumatic fever and Class-II is responsible for acute glomerulonephri...
References:
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Disease manifestations and pathogenic mechanisms of Group A Streptococcus.
Clin Microbiol Rev. 2014 Apr;27(2):264-301. doi: 10.1128/CMR.00101-13. -
Proteome driven re-evaluation and functional annotation of the Streptococcus pyogenes SF370 genome.
BMC Microbiol. 2011 Nov 10;11:249. doi: 10.1186/1471-2180-11-249. -
Streptococcal 5'-Nucleotidase A (S5nA), a Novel Streptococcus pyogenes Virulence Factor That Facilitates Immune
Evasion. J Biol Chem. 2015 Dec 25;290(52):31126-37. doi: 10.1074/jbc.M115.677443. Epub 2015 Nov 2. -
Cell wall structure and function in lactic acid bacteria.
Microb Cell Fact. 2014 Aug 29;13 Suppl 1(Suppl 1):S9. doi: 10.1186/1475-2859-13-S1-S9. Epub 2014 Aug 29.
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