D-Alanine Metabolism

Description:

The bacterial cell wall is a unique biopolymer, containing both D- and L-Amino acids. Its basic structure is a carbohydrate backbone of alternating units of N-Acetyl Glucosamine and N-Acetyl Muramic Acid. The N-Acetyl Muramic Acid residues are cross-linked with oligopeptides. The terminal peptide is D-Alanine although other amino acids are present as D- isomers and this is the only known biological molecule that contains D-Amin[...]

References:

Structural perspective of peptidoglycan biosynthesis and assembly.
Lovering AL, Safadi SS, Strynadka NC.
Annu Rev Biochem. 2012;81:451-78. doi: 10.1146/annurev-biochem-061809-112742.
D-Cycloserine destruction by alanine racemase and the limit of irreversible inhibition.
de Chiara C, Homšak M, Prosser GA, Douglas HL, Garza-Garcia A, Kelly G, Purkiss AG, Tate EW, de Carvalho LPS.
Nat Chem Biol. 2020 Jun;16(6):686-694. doi: 10.1038/s41589-020-0498-9. Epub 2020 Mar 16.
Structural basis of peptidoglycan endopeptidase regulation.
Shin JH, Sulpizio AG, Kelley A, Alvarez L, Murphy SG, Fan L, Cava F, Mao Y, Saper MA, Dörr T.
Proc Natl Acad Sci U S A. 2020 May 26;117(21):11692-11702. doi: 10.1073/pnas.2001661117. Epub 2020 May 11.
Wall teichoic acids of gram-positive bacteria.
Brown S, Santa Maria JP Jr, Walker S.
Annu Rev Microbiol. 2013;67:313-36. doi: 10.1146/annurev-micro-092412-155620.
Functional and structural characterization of thermostable D-amino acid aminotransferases from Geobacillus spp.
Lee SG, Hong SP, Song JJ, Kim SJ, Kwak MS, Sung MH.
Appl Environ Microbiol. 2006 Feb;72(2):1588-94. doi: 10.1128/AEM.72.2.1588-1594.2006.
A Survey of Pyridoxal 5'-Phosphate-Dependent Proteins in the Gram-Positive Model Bacterium Bacillus subtilis.
Richts B, Rosenberg J, Commichau FM.
Front Mol Biosci. 2019 May 10;6:32. doi: 10.3389/fmolb.2019.00032.
Identification and characterization of the DdlB, FtsQ and FtsA genes upstream of FtsZ in Bartonella bacilliformis and Bartonella henselae.
Fiskus W, Padmalayam I, Kelly T, Guibao C, Baumstark BR.
DNA Cell Biol. 2003 Nov;22(11):743-52
-Alanine-d-alanine ligase as a model for the activation of ATP-grasp enzymes by monovalent cations.
Pederick JL, Thompson AP, Bell SG, Bruning JB.
J Biol Chem. 2020 Jun 5;295(23):7894-7904. doi: 10.1074/jbc.RA120.012936. Epub 2020 Apr 25.

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Pathways

D-Alanine Metabolism

Description:

References:

Structural perspective of peptidoglycan biosynthesis and assembly.

D-Cycloserine destruction by alanine racemase and the limit of irreversible inhibition.

Structural basis of peptidoglycan endopeptidase regulation.

Wall teichoic acids of gram-positive bacteria.

Functional and structural characterization of thermostable D-amino acid aminotransferases from Geobacillus spp.

A Survey of Pyridoxal 5'-Phosphate-Dependent Proteins in the Gram-Positive Model Bacterium Bacillus subtilis.

Identification and characterization of the DdlB, FtsQ and FtsA genes upstream of FtsZ in Bartonella bacilliformis and Bartonella henselae.

-Alanine-d-alanine ligase as a model for the activation of ATP-grasp enzymes by monovalent cations.

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D-Alanine Metabolism

Description:

References:

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