Pathways
D-Alanine Metabolism
Description:
The bacterial cell wall is a unique biopolymer, containing both D- and L-Amino acids. Its basic structure is a carbohydrate backbone of alternating units of N-Acetyl Glucosamine and N-Acetyl Muramic Acid. The N-Acetyl Muramic Acid residues are cross-linked with oligopeptides. The terminal peptide is D-Alanine although other amino acids are present as D- isomers and this is the only known biological molecule that contains D-Amino acids, which are responsible for the building of peptidoglycan. The cell wall of Gram-positive bac...
References:
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Structural perspective of peptidoglycan biosynthesis and assembly.
Annu Rev Biochem. 2012;81:451-78. doi: 10.1146/annurev-biochem-061809-112742. -
D-Cycloserine destruction by alanine racemase and the limit of irreversible inhibition.
Nat Chem Biol. 2020 Jun;16(6):686-694. doi: 10.1038/s41589-020-0498-9. Epub 2020 Mar 16. -
Structural basis of peptidoglycan endopeptidase regulation.
Proc Natl Acad Sci U S A. 2020 May 26;117(21):11692-11702. doi: 10.1073/pnas.2001661117. Epub 2020 May 11. -
Wall teichoic acids of gram-positive bacteria.
Annu Rev Microbiol. 2013;67:313-36. doi: 10.1146/annurev-micro-092412-155620.
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