Aldosterone Signaling in Epithelial Cells

Description:

Sodium transport across the tight epithelia of Na+ reabsorbing tissues such as the distal nephron and colon is the major factor determining total body Na+ levels, and thus, long term blood pressure. Aldosterone, a steroid hormone that is primarily produced in the outer layer of the adrenal cortex, maintains total organism sodium balance in all higher vertebrates. Principally, in humans, aldosterone is involved in the regulation of[...]

References:

Aldosterone signaling and soluble adenylyl cyclase-a nexus for the kidney and vascular endothelium.
Schmitz B, Brand SM, Brand E.
Biochim Biophys Acta. 2014 Dec; 1842(12 Pt B):2601-9. doi: 10.1016/j.bbadis.2014.05.036. Epub 2014 Jun 5. Review.
Mechanisms underlying rapid aldosterone effects in the kidney.
Thomas W, Harvey BJ.
Annu Rev Physiol. 2011; 73:335-57. doi: 10.1146/annurev-physiol-012110-142222. Review.
Mechanisms of mineralocorticoid action.
Fuller PJ, Young MJ.
Hypertension. 2005 Dec; 46(6):1227-35. Epub 2005 Nov 14. Review.
Phosphorylation of Mineralocorticoid Receptor Ligand Binding Domain Impairs Receptor Activation and Has a Dominant Negative Effect over Non-phosphorylated Receptors.
Jiménez-Canino R, Fernandes MX, Alvarez de la Rosa D.
J Biol Chem. 2016 Sep 2; 291(36):19068-78. doi: 10.1074/jbc.M116.718395. Epub 2016 Jul 15.
Genomic and non-genomic effects of glucocorticoids: implications for breast cancer.
Mitre-Aguilar IB, Cabrera-Quintero AJ, Zentella-Dehesa A.
Int J Clin Exp Pathol. 2015 Jan 1; 8(1):1-10. eCollection 2015. Review.
Regulation of Na+ transport by aldosterone: signaling convergence and cross talk between the PI3-K and MAPK1/2 cascades.
Tong Q, Booth RE, Worrell RT, Stockand JD.
Am J Physiol Renal Physiol. 2004 Jun; 286(6):F1232-8. Epub 2004 Mar 23.
Aldosterone, SGK1, and ion channels in the kidney.
Valinsky WC, Touyz RM, Shrier A.
Clin Sci (Lond). 2018 Jan 19; 132(2):173-183. doi: 10.1042/CS20171525. Print 2018 Jan 31. Review.
Mechanisms of aldosterone's action on epithelial Na + transport.
Eaton DC, Malik B, Saxena NC, Al-Khalili OK, Yue G.
J Membr Biol. 2001 Dec 1; 184(3):313-9. Epub 2002 Feb 5. Review.
Addison's disease: identification and management in primary care.
Burton C, Cottrell E, Edwards J.
Br J Gen Pract. 2015 Sep; 65(638):488-90. doi: 10.3399/bjgp15X686713. No abstract available.
Management of glucocorticoid replacement in adrenal insufficiency shows notable heterogeneity - datafrom the EU-AIR.
Murray RD, Ekman B, Uddin S, Marelli C, Quinkler M, Zelissen PM; the EU-AIR Investigators.
Clin Endocrinol (Oxf). 2017 Mar; 86(3):340-346. doi: 10.1111/cen.13267. Epub 2016 Dec 5.
Heritable forms of hypertension.
Vehaskari VM.
Pediatr Nephrol. 2009 Oct; 24(10):1929-37. Epub 2007 Jul 24. Review.

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Pathways

Aldosterone Signaling in Epithelial Cells

Description:

References:

Aldosterone signaling and soluble adenylyl cyclase-a nexus for the kidney and vascular endothelium.

Mechanisms underlying rapid aldosterone effects in the kidney.

Mechanisms of mineralocorticoid action.

Phosphorylation of Mineralocorticoid Receptor Ligand Binding Domain Impairs Receptor Activation and Has a Dominant Negative Effect over Non-phosphorylated Receptors.

Genomic and non-genomic effects of glucocorticoids: implications for breast cancer.

Regulation of Na+ transport by aldosterone: signaling convergence and cross talk between the PI3-K and MAPK1/2 cascades.

Aldosterone, SGK1, and ion channels in the kidney.

Mechanisms of aldosterone's action on epithelial Na + transport.

Addison's disease: identification and management in primary care.

Management of glucocorticoid replacement in adrenal insufficiency shows notable heterogeneity - datafrom the EU-AIR.

Heritable forms of hypertension.

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Aldosterone Signaling in Epithelial Cells

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