Aldosterone Signaling in Epithelial Cells

Description:

Sodium transport across the tight epithelia of Na+ reabsorbing tissues such as the distal nephron and colon is the major factor determining total body Na+ levels, and thus, long term blood pressure. Aldosterone, a steroid hormone that is primarily produced in the outer layer of the adrenal cortex, maintains total organism sodium balance in all higher vertebrates. Principally, in humans, aldosterone is involved in the regulation of electrolyte and water balance through its effects on ion transport in epithelial cells. Electricall...

References:

Aldosterone signaling and soluble adenylyl cyclase-a nexus for the kidney and vascular endothelium.
Schmitz B, Brand SM, Brand E.
Biochim Biophys Acta. 2014 Dec; 1842(12 Pt B):2601-9. doi: 10.1016/j.bbadis.2014.05.036. Epub 2014 Jun 5. Review.
Mechanisms underlying rapid aldosterone effects in the kidney.
Thomas W, Harvey BJ.
Annu Rev Physiol. 2011; 73:335-57. doi: 10.1146/annurev-physiol-012110-142222. Review.
Mechanisms of mineralocorticoid action.
Fuller PJ, Young MJ.
Hypertension. 2005 Dec; 46(6):1227-35. Epub 2005 Nov 14. Review.
Phosphorylation of Mineralocorticoid Receptor Ligand Binding Domain Impairs Receptor Activation and Has a Dominant Negative Effect over Non-phosphorylated Receptors.
Jiménez-Canino R, Fernandes MX, Alvarez de la Rosa D.
J Biol Chem. 2016 Sep 2; 291(36):19068-78. doi: 10.1074/jbc.M116.718395. Epub 2016 Jul 15.

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Aldosterone Signaling in Epithelial Cells

Description:

References:

Aldosterone signaling and soluble adenylyl cyclase-a nexus for the kidney and vascular endothelium.

Mechanisms underlying rapid aldosterone effects in the kidney.

Mechanisms of mineralocorticoid action.

Phosphorylation of Mineralocorticoid Receptor Ligand Binding Domain Impairs Receptor Activation and Has a Dominant Negative Effect over Non-phosphorylated Receptors.

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Aldosterone Signaling in Epithelial Cells

Description:

References:

Aldosterone signaling and soluble adenylyl cyclase-a nexus for the kidney and vascular endothelium.

Mechanisms underlying rapid aldosterone effects in the kidney.

Mechanisms of mineralocorticoid action.

Phosphorylation of Mineralocorticoid Receptor Ligand Binding Domain Impairs Receptor Activation and Has a Dominant Negative Effect over Non-phosphorylated Receptors.

Databases

Tools

Institutional License

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