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Aldosterone Signaling in Epithelial Cells


Sodium transport across the tight epithelia of Na+ reabsorbing tissues such as the distal nephron and colon is the major factor determining total body Na+ levels, and thus, long term blood pressure. Aldosterone, a steroid hormone that is primarily produced in the outer layer of the adrenal cortex, maintains total organism sodium balance in all higher vertebrates. Principally, in humans, aldosterone is involved in the regulation of[...]




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