Pathways
all-trans-Retinoic Acid Signaling in Brain
Description:
Retinoic Acid, the active form of Vitamin-A (all-trans-Retinol), is a lipophilic molecule, and is known to affect gene transcription. Retinoic Acid is made available in the body through dietary intake and subsequent metabolism in the liver. Vitamin-A is secreted from its storage pools and circulates in blood. In the liver Vitamin-A is converted to all-trans-Retinoic acid, the Carboxylic Acid form of Vitamin-A and diffuses easily to the target tissues through cellular membranes; gets bound to CRABP (Cellular Retinoic Acid Binding...
References:
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Role of retinoids in the prevention and treatment of colorectal cancer.
World J Gastrointest Oncol. 2015 Oct 15;7(10):184-203. doi: 10.4251/wjgo.v7.i10.184. Review. -
Retinoids and rexinoids in cancer prevention: from laboratory to clinic.
Semin Oncol. 2016 Feb;43(1):49-64. doi: 10.1053/j.seminoncol.2015.09.002. Epub 2015 Sep 25. Review. -
Cell survival signalling through PPARδ and arachidonic acid metabolites in neuroblastoma.
PLoS One. 2013 Jul 9;8(7):e68859. doi: 10.1371/journal.pone.0068859. Print 2013. -
Involvement of cytosolic phospholipase A(2), calcium independent phospholipase A(2) and plasmalogen selective phospholipase A(2) in neurodegenerative and neuropsychiatric conditions.
Curr Med Chem. 2010;17(25):2746-63. Review.
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