Pathways
Allergic Response Pathway
Description:
Atopy or Allergic disease is a complex familial disorder with multiple manifestations, including allergic asthma, rhinitis, conjunctivitis, and dermatitis. Allergens are derived from different sources such as cockroaches, ragweed pollens, and house dust mites. The primary immune cell lineages involved in the initiation and progression of allergic inflammation include DCs (Dendritic Cells), mast cells, basophils, eosinophils, and Th2 (Type-2 Helper T) cells. The responses of these principal players in allergic reactions are in...
References:
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The Role of Dust Mites in Allergy.
Clin Rev Allergy Immunol. 2018 Jun 23. doi: 10.1007/s12016-018-8693-0. [Epub ahead of print] Review. -
Key mediators in the immunopathogenesis of allergic asthma.
Int Immunopharmacol. 2014 Nov;23(1):316-29. doi: 10.1016/j.intimp.2014.05.034. Epub 2014 Jun 13. Review. -
Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data.
Nat Rev Immunol. 2007 Feb;7(2):93-104. -
IgE and mast cells in allergic disease.
Nat Med. 2012 May 4;18(5):693-704. doi: 10.1038/nm.2755.
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