Alpha-Adrenergic Signaling

Description:

ADRs (Adrenergic Receptors) are expressed on virtually every cell type in the body and are the receptors for Adrenaline, Epinephrine and Norepinephrine within the Sympathetic Nervous System. They serve critical roles in maintaining homeostasis in normal physiologic settings as well as pathologic states. These receptors are also targets for therapeutically administered agonists and antagonists (Ref.1). ADRs are members of the super family of cell surface receptors that carry out signaling via GPCR (G-Protein Coupled Receptors) an...

References:

Polymorphic variants of adrenoceptors: pharmacology, physiology, and role in disease.
Ahles A, Engelhardt S.
Pharmacol Rev. 2014 Jul;66(3):598-637. doi: 10.1124/pr.113.008219. Review.
Cardiac alpha1-adrenergic receptors: novel aspects of expression, signaling mechanisms, physiologic function, and clinical importance.
O'Connell TD, Jensen BC, Baker AJ, Simpson PC.
Pharmacol Rev. 2013 Dec 24;66(1):308-33. doi: 10.1124/pr.112.007203. Print 2014. Review.
Effects of α2A Adrenoceptors on Norepinephrine Secretion from the Locus Coeruleus during Chronic Stress-Induced Depression.
Wang B, Wang Y, Wu Q, Huang HP, Li S.
Front Neurosci. 2017 May 1;11:243. doi: 10.3389/fnins.2017.00243. eCollection 2017.
In vivo gene modification elucidates subtype-specific functions of alpha (2)-adrenergic receptors
Kable JW, Murrin LC, Bylund DB
J Pharmacol Exp Ther. 2000 Apr; 293(1): 1-7.

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Alpha-Adrenergic Signaling

Description:

References:

Polymorphic variants of adrenoceptors: pharmacology, physiology, and role in disease.

Cardiac alpha1-adrenergic receptors: novel aspects of expression, signaling mechanisms, physiologic function, and clinical importance.

Effects of α2A Adrenoceptors on Norepinephrine Secretion from the Locus Coeruleus during Chronic Stress-Induced Depression.

In vivo gene modification elucidates subtype-specific functions of alpha (2)-adrenergic receptors

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Alpha-Adrenergic Signaling

Description:

References:

Polymorphic variants of adrenoceptors: pharmacology, physiology, and role in disease.

Cardiac alpha1-adrenergic receptors: novel aspects of expression, signaling mechanisms, physiologic function, and clinical importance.

Effects of α2A Adrenoceptors on Norepinephrine Secretion from the Locus Coeruleus during Chronic Stress-Induced Depression.

In vivo gene modification elucidates subtype-specific functions of alpha (2)-adrenergic receptors

Databases

Tools

Institutional License

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