G-AlphaI Signaling

Description:

The heterotrimeric G-Proteins (Guanine nucleotide-binding Proteins) are signal transducers that communicate signals from many hormones, neurotransmitters, chemokines, and autocrine and paracrine factors. The extracellular signals are received by members of a large superfamily of receptors with seven membrane-spanning regions, known as GPCR (G-Protein Coupled Receptor), that activate the G-proteins, which route the signals to several distinct intracellular signaling pathways. These pathways interact with one another to form a ...

References:

Novel insights into G protein and G protein-coupled receptor signaling in cancer.
O'Hayre M, Degese MS, Gutkind JS.
Curr Opin Cell Biol. 2014 Apr;27:126-35. doi: 10.1016/j.ceb.2014.01.005. Epub 2014 Feb 6. Review.
Distinct profiles of functional discrimination among G proteins determine the actions of G protein-coupled receptors.
Masuho I, Ostrovskaya O, Kramer GM, Jones CD, Xie K, Martemyanov KA.
Sci Signal. 2015 Dec 1;8(405):ra123. doi: 10.1126/scisignal.aab4068.
Conformational dynamics of a G-protein a subunit is tightly regulated by nucleotide binding.
Goricanec D, Stehle R, Egloff P, Grigoriu S, Plückthun A, Wagner G, Hagn F.
Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3629-38. doi: 10.1073/pnas.1604125113. Epub 2016 Jun 13.
Gi proteins regulate adenylyl cyclase activity independent of receptor activation.
Melsom CB, Ørstavik Ø, Osnes JB, Skomedal T, Levy FO, Krobert KA.
PLoS One. 2014 Sep 9;9(9):e106608. doi: 10.1371/journal.pone.0106608. eCollection 2014.

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Pathways

G-AlphaI Signaling

Description:

References:

Novel insights into G protein and G protein-coupled receptor signaling in cancer.

Distinct profiles of functional discrimination among G proteins determine the actions of G protein-coupled receptors.

Conformational dynamics of a G-protein a subunit is tightly regulated by nucleotide binding.

Gi proteins regulate adenylyl cyclase activity independent of receptor activation.

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Institutional License

Pathways

G-AlphaI Signaling

Description:

References:

Novel insights into G protein and G protein-coupled receptor signaling in cancer.

Distinct profiles of functional discrimination among G proteins determine the actions of G protein-coupled receptors.

Conformational dynamics of a G-protein a subunit is tightly regulated by nucleotide binding.

Gi proteins regulate adenylyl cyclase activity independent of receptor activation.

Databases

Tools

Institutional License

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