Pathways
G-AlphaQ Signaling
Description:
GPCR (G-Protein-Coupled Receptors) constitute a large and diverse family of proteins whose primary function is to transduce extracellular stimuli into intracellular signals. They are among the largest and most diverse protein families in mammalian genomes. Also termed Serpentine receptors, GPCRs are polytopic membrane proteins that share a common structure with seven transmembrane segments, but sequence similarity is minimal among the most distant GPCRs. GPCRs recognize a variety of ligands and stimuli including Peptide and n...
References:
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Minireview: Role of intracellular scaffolding proteins in the regulation of endocrine G protein-coupled receptor signaling.
Mol Endocrinol. 2015 Jun;29(6):814-30. doi: 10.1210/me.2015-1091. Epub 2015 May 5. Review. -
Regulators of G-protein signaling and their Ga substrates: promises and challenges in their use as drug discovery targets.
Pharmacol Rev. 2011 Sep;63(3):728-49. doi: 10.1124/pr.110.003038. Epub 2011 Jul 7. Review. -
Probing heterotrimeric G protein activation: applications to biased ligands.
Curr Pharm Des. 2012;18(2):128-44. Review. -
Gq-Coupled Receptors in Autoimmunity.
J Immunol Res. 2016;2016:3969023. doi: 10.1155/2016/3969023. Epub 2016 Jan 17. Review.
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