Pathways
Alternative Complement Pathway
Description:
The complement system refers to a series of proteins circulating in the blood and bathing the fluids surrounding tissues. The proteins circulate in an inactive form, but in response to the recognition of molecular components of microorganism, they become sequentially activated, working in a cascade where in the binding of one protein promotes the binding of the next protein in the cascade. There are 3 complement pathways that make up the complement system: the classical complement pathway, the lectin pathway, and the alternative...
References:
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Complement System Part II: Role in Immunity.
Front Immunol. 2015 May 26;6:257. doi: 10.3389/fimmu.2015.00257. eCollection 2015. Review. -
Quantitative Modeling of the Alternative Pathway of the Complement System.
PLoS One. 2016 Mar 31;11(3):e0152337. doi: 10.1371/journal.pone.0152337. eCollection 2016. -
Autoantibodies against alternative complement pathway proteins in renal pathologies.
Nefrologia. 2016 Sep - Oct;36(5):489-495. doi: 10.1016/j.nefro.2016.01.014. Epub 2016 Jun 3. English, Spanish. -
Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex.
EMBO J. 2011 Feb 2;30(3):606-16. doi: 10.1038/emboj.2010.341. Epub 2011 Jan 7.
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