Pathways
AMPK Enzyme Complex Pathway
Description:
One of the key functions of catabolic metabolism is to maintain high levels of ATP (Adenosine Triphosphate) and cells rapidly respond to any stress that threatens to lower ATP levels by arresting non-essential ATP-utilizing functions and stimulating available ATP-generating pathways. A central player in this system is the AMPK (AMP (Adenosine 5'-Monophosphate)-Activated Protein Kinase). AMPK is a master metabolic regulator responsible for modulating cellular responses to an energy challenge. The evolutionarily conserved Serine/T...
References:
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AMPK: guardian of metabolism and mitochondrial homeostasis.
Nat Rev Mol Cell Biol. 2017 Oct 4. doi: 10.1038/nrm.2017.95. [Epub ahead of print] Review. -
The Warburg effect and drug resistance.
Br J Pharmacol. 2016 Mar;173(6):970-9. doi: 10.1111/bph.13422. Epub 2016 Feb 18. Review. -
ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway.
Mol Cancer. 2017 Apr 13;16(1):79. doi: 10.1186/s12943-017-0648-1. Review. -
The role of AMP-activated protein kinase in the coordination of skeletal muscle turnover and energy homeostasis.
Am J Physiol Cell Physiol. 2012 Sep 1;303(5):C475-85. doi: 10.1152/ajpcell.00125.2012. Epub 2012 Jun 13. Review.
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