Pathways
Angiopoietin-TIE2 Signaling
Description:
Development of a functional cardiovascular system is dependent on the regulated proliferation, migration, and differentiation of endothelial cells in two discrete processes known as vasculogenesis and angiogenesis. Angiogenesis is the formation of new capillaries from pre-existing vessels, whereas vasculogenesis is de-novo capillary formation from EPCs (Endothelial Precursor Cells). New capillaries arise from preexisting larger vessels to give rise to a more complex vascular network with a hierarchy of both large and small ve...
References:
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Vascular Endothelial Growth Factor and Angiogenesis in the Regulation of Cutaneous Wound Repair.
Adv Wound Care (New Rochelle). 2014 Oct 1;3(10):647-661. Review. -
miRNAs as modulators of angiogenesis.
Cold Spring Harb Perspect Med. 2013 Feb 1;3(2):a006643. doi: 10.1101/cshperspect.a006643. Review. -
Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization.
Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4376-4381. doi: 10.1073/pnas.1616166114. Epub 2017 Apr 10. -
Angiopoietin-Tie signalling in the cardiovascular and lymphatic systems.
Clin Sci (Lond). 2017 Jan 1;131(1):87-103. Review.
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