Pathways
Antigen Processing and Presentation by MHCs
Description:
In order to initiate a specific immune response to an infectious agent, the immune system must be able to wade through the sea of molecules that are associated with pathogenic invasion and isolate particular protein products that will sharpen the efforts of host defense. Implicit to this model of counteraction is the processing of an immunogenic peptide epitope (Antigen Processing) and its presentation on the surface of a team of cells, referred to as APCs (Antigen Presenting Cells) (Antigen Presentation). The result of these ac...
References:
-
Endogenous viral antigen processing generates peptide-specific MHC class I cell-surface clusters.
Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15407-12. Epub 2012 Sep 4. -
Prediction of peptides binding to MHC class I and II alleles by temporal motif mining.
BMC Bioinformatics. 2013;14 Suppl 2:S13. doi: 10.1186/1471-2105-14-S2-S13. Epub 2013 Jan 21. -
Pathways of antigen processing.
Annu Rev Immunol. 2013;31:443-73. doi: 10.1146/annurev-immunol-032712-095910. Epub 2013 Jan 3. Review. -
Peptide-independent stabilization of MHC class I molecules breaches cellular quality control.
J Cell Sci. 2014 Jul 1;127(Pt 13):2885-97. doi: 10.1242/jcs.145334. Epub 2014 May 7.
You can view details of this pathway by subscribing:
9853 Pacific Heights Blvd.
Suite D., San Diego, CA 92121, USA
Tel: 858-224-2869
Fax: 858-205-1192
info@proteinlounge.com
Databases
Tools
Institutional License
Need our databases and tools to be availed by your whole university or institute? We recommend signing up for our Site License.
To set up a license, please contact: info@proteinlounge.com
Copyright © Protein Lounge Inc.
Terms & Conditions