Pathways
Antioxidant Action of Vitamin-C
Description:
Oxidative stress/Hypoxia is induced by a wide range of environmental factors including UV stress, pathogen invasion (hypersensitive reaction), oxygen shortage, etc. Generation of ROS (Reactive Oxygen Species) is characteristic feature of such stress conditions. Of the ROS, both Hydrogen Peroxide and Superoxide are produced in a number of cellular reactions and by various enzymes such as Lipoxygenases, Peroxidases, NADPH Oxidase, Xanthine Oxidase, etc to name a few. The main cellular components susceptible to damage by free ra...
References:
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The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state.
Nutr J. 2016 Jul 25;15(1):71. doi: 10.1186/s12937-016-0186-5. Review. -
Oxidative stress and antioxidant defense.
World Allergy Organ J. 2012 Jan;5(1):9-19. doi: 10.1097/WOX.0b013e3182439613. Epub 2012 Jan 13. -
High-Dose Vitamin C Injection to Cancer Patients May Promote Thrombosis Through Procoagulant Activation of Erythrocytes.
Toxicol Sci. 2015 Oct;147(2):350-9. doi: 10.1093/toxsci/kfv133. Epub 2015 Jul 2. -
Contribution of oxidative stress to endothelial dysfunction in hypertension.
Front Physiol. 2012 Dec 5;3:441. doi: 10.3389/fphys.2012.00441. eCollection 2012.
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