Pathways
Antiproliferative Role of SSTR2
Description:
Somatostatin is a widely distributed peptide hormone that plays an important inhibitory role in several biological processes, including neurotransmission, exocrine and endocrine secretions, and cell proliferation (Ref.1). Somatostatin acts via a family of five GPCRs (G-Protein-Coupled Receptors) SSTR1-SSTR5 (Somatostatin Receptors) that are variably expressed throughout numerous tissues ranging from the CNS (Central Nervous System) to the Endocrine and Immune Systems. Somatostatin antiproliferative action results either from inh...
References:
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Down-regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype 5: a novel mechanism for inhibition of cellular proliferation and insulin secretion by somatostatin.
Front Physiol. 2014 Jun 25;5:226. doi: 10.3389/fphys.2014.00226. eCollection 2014. Review. -
Differential somatostatin receptor (SSTR) 1- expression and downstream effectors in histologic subtypesof growth hormone pituitary tumors.
Mol Cell Endocrinol. 2015 Dec 5;417:73-83. doi: 10.1016/j.mce.2015.09.016. Epub 2015 Sep 21. -
Peptide receptor targeting in cancer: the somatostatin paradigm.
Int J Pept. 2013;2013:926295. doi: 10.1155/2013/926295. Epub 2013 Feb 7. -
Somatostatin receptor ligands and resistance to treatment in pituitary adenomas.
J Mol Endocrinol. 2014 Jun;52(3)R223-40. doi 10.1530JME-14-0011. Epub 2014 Mar 19. Review.
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