Pathways
Apoptosis in Drosophila
Description:
Apoptosis refers to an evolutionarily conserved method of Cell Death that is characterized by specific morphological and biochemical properties. Morphologically, Apoptosis is characterized by a series of structural changes in dying cells: Blebbing of the plasma membrane, Condensation of the cytoplasm and nucleus, and Cellular Fragmentation into membrane Apoptotic bodies. Biochemically, Apoptosis is characterized by the degradation of Chromatin, initially into large fragments of 50-300 kilobases and subsequently into sma...
References:
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Programmed cell death in the embryonic central nervous system of Drosophila melanogaster.
Development. 2007 Jan;134(1):105-16. -
Drosophila IAP antagonists form multimeric complexes to promote cell death.
J Cell Biol. 2010 Sep 20;190(6):1039-52. doi: 10.1083/jcb.201004086. Epub 2010 Sep 13. -
NOPO modulates Egr-induced JNK-independent cell death in Drosophila.
Cell Res. 2012 Feb;22(2):425-31. doi: 10.1038/cr.2011.135. Epub 2011 Aug 16. -
Caspase-dependent non-apoptotic processes in development.
Cell Death Differ. 2017 Aug;24(8):1422-1430. doi: 10.1038/cdd.2017.36. Epub 2017 May 19. Review.
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