Apoptosis through Death Receptors

Description:

Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival. Certain cells have unique sensors, termed DR (Death Receptors), on their surface, which detect the presence of extracellular death signals and, in response; they rapidly ignite the cell's intrinsic apoptosis machinery. Death Receptors belong to the TNF (Tumour Necrosis Factor) gene superfamily and generally can have several functions other than initiating apoptosis....

References:

Fas death receptor signalling: roles of Bid and XIAP.
Kaufmann T, Strasser A, Jost PJ.
Cell Death Differ. 2012 Jan;19(1):42-50. doi: 10.1038/cdd.2011.121. Epub 2011 Sep 30.
Death receptor-ligand systems in cancer, cell death, and inflammation.
Walczak H.
Cold Spring Harb Perspect Biol. 2013 May 1;5(5):a008698. doi: 10.1101/cshperspect.a008698. Review.
Cleavage by Caspase 8 and Mitochondrial Membrane Association Activate the BH3-only Protein Bid during TRAIL-induced Apoptosis.
Huang K, Zhang J, O'Neill KL, Gurumurthy CB, Quadros RM, Tu Y, Luo X.
J Biol Chem. 2016 May 27;291(22):11843-51. doi: 10.1074/jbc.M115.711051.Epub 2016 Apr 6.
Regulating TRAIL receptor-induced cell death at the membrane : a deadly discussion.
Shirley S, Morizot A, Micheau O.
Recent Pat Anticancer Drug Discov. 2011 Sep;6(3):311-23.

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Pathways

Apoptosis through Death Receptors

Description:

References:

Fas death receptor signalling: roles of Bid and XIAP.

Death receptor-ligand systems in cancer, cell death, and inflammation.

Cleavage by Caspase 8 and Mitochondrial Membrane Association Activate the BH3-only Protein Bid during TRAIL-induced Apoptosis.

Regulating TRAIL receptor-induced cell death at the membrane : a deadly discussion.

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Apoptosis through Death Receptors

Description:

References:

Fas death receptor signalling: roles of Bid and XIAP.

Death receptor-ligand systems in cancer, cell death, and inflammation.

Cleavage by Caspase 8 and Mitochondrial Membrane Association Activate the BH3-only Protein Bid during TRAIL-induced Apoptosis.

Regulating TRAIL receptor-induced cell death at the membrane : a deadly discussion.

Databases

Tools

Institutional License

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