Pathways
Apoptotic Pathways Triggered By HIV1
Description:
Apoptosis, necroptosis, and pyroptosis are the three major ways of PCD(programed cell death) following virus infection. Among them, apoptosis is the most extensively investigated PCD during viral infection. Apoptosis elicited by virus infection has both negative and positive influence on viral replication.Apoptosis is triggered by two distinct signaling pathways, namely the intrinsic and extrinsic pathways(Ref.1).
The intrinsic apoptotic pathway is elicited by a wide range of intracellular stress conditions, including cyt...
The intrinsic apoptotic pathway is elicited by a wide range of intracellular stress conditions, including cyt...
References:
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Virus Infection and Death Receptor-Mediated Apoptosis.
Viruses. 2017 Oct 27;9(11). pii: E316. doi: 10.3390/v9110316. Review. -
T-Cell Signaling in HIV-1 Infection.
Open Virol J. 2013 Jul 26;7:57-71. doi: 10.2174/1874357920130621001. eCollection 2013. -
HIV-1 activates macrophages independent of Toll-like receptors.
PLoS One. 2008;3(12):e3664. doi: 10.1371/journal.pone.0003664. Epub 2008 Dec 2. -
Human immunodeficiency virus-1 (HIV-1)-mediated apoptosis: new therapeutic targets.
Viruses. 2014 Aug 19;6(8):3181-227. doi: 10.3390/v6083181. Review.
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