Pathways
APRIL Pathway
Description:
APRIL (a proliferation-inducing ligand, also known as TRDL-1, TALL-2, and TNFSF13), is a member of the TNF (tumor necrosis factor) superfamily, with homologous structure and function to several other cytokines in this family. It is a cytokine which is over-expressed by transformed cells and could stimulate cellular proliferation (Ref.1) It has two receptors i.e BCMA and TACI (Tumor necrosis factor receptor superfamily members 17 and 13B) that play important roles in the B-cell and T-cell arms of the immune system (Ref.2 & 3). ...
References:
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APRIL induces tumorigenesis and metastasis of colorectal cancer cells via activation of the PI3K/Akt pathway.
PLoS One. 2013; 8(1):e55298. doi: 10.1371/journal.pone.0055298. Epub 2013 Jan 29. -
APRIL:TACI axis is dispensable for the immune response to rabies vaccination.
Antiviral Res. 2017 Aug;144:130-137. doi: 10.1016/j.antiviral.2017.06.004. Epub 2017 Jun 12. -
Soluble TACI and soluble BCMA as biomarkers in primary central nervous system lymphoma.
Neuro Oncol. 2017 May 17. doi: 10.1093/neuonc/nox097. [Epub ahead of print] -
Non-Canonical NF-κB Signaling Initiated by BAFF Influences B Cell Biology at Multiple Junctures.
Front Immunol. 2014 Jan 6;4:509. doi: 10.3389/fimmu.2013.00509. eCollection 2014 Jan 6.
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