Pathways
Assembly of RNA Polymerase-II Initiation Complex
Description:
The nuclei of all eukaryotic cells contain three different RNA Polymerases, designated I, II and III. Like the DNA Polymerase that catalyzes DNA replication, RNA Polymerases catalyze the formation of the phosphodiester bonds that link the nucleotides together to form a linear chain. Each eukaryotic RNA Polymerase catalyzes transcription of genes encoding different classes of RNA. RNA Polymerase-II catalyzes transcription of all protein-coding genes; that is, it functions in production of mRNAs. RNA Polymerase-II also produces...
References:
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TFIIB-related factors in RNA polymerase I transcription.
Biochim Biophys Acta. 2013 Mar-Apr;1829(3-4):265-73. doi: 10.1016/j.bbagrm.2012.08.003. Epub 2012 Aug 30. Review. -
Regulation of expression of human RNA polymerase II-transcribed snRNA genes.
Open Biol. 2017 Jun; 7(6): 170073. Published online 2017 Jun 14. doi: 10.1098/rsob.170073 -
The RNA polymerase II preinitiation complex. Through what pathway is the complex assembled?
Transcription. 2014;5(1):e27050. doi: 10.4161/trns.27050. Review. -
TFIIH generates a six-base-pair open complex during RNAP II transcription initiation and start-site scanning.
Nat Struct Mol Biol. 2017 Dec;24(12):1139-1145. doi: 10.1038/nsmb.3500. Epub 2017 Nov 6.
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