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Pathways

Assembly of RNA Polymerase-I Initiation Complex

Description:

The nuclei of all eukaryotic cells contain three different RNA Polymerases, designated I, II and III. Like the DNA polymerase that catalyzes DNA replication, RNA Polymerases catalyze the formation of the phosphodiester bonds that link the nucleotides together to form a linear chain. The RNA polymerase moves stepwise along the DNA, unwinding the DNA helix just ahead of the active site for polymerization to expose a new region of th[...]

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