ATM Pathway

Description:

ATM (Ataxia Telangiectasia Mutated Protein) belongs to a family of Kinases that have sequence homology to PI3K (Phosphoinositide 3-Kinase).ATM is a key regulator of multiple signaling cascades which respond to DNA strand breaks induced by damaging agents IR (Ionizing Radiation), radiometric agents or by normal processes. These responses involve the activation of cell cycle CHK factors (Checkpoints factors), DNA repair and Apoptosis. Its downstream targets include CHK1 (Cell Cycle Checkpoint Kinase-1), CHK2 (Cell Cycle Checkpo...

References:

ATM kinase promotes both caspase-8 and caspase-9 activation during TNF-a-induced apoptosis of HeLa cells.
Liu L, Yim H, Choi JH, Kim ST, Jin Y, Lee SK.
FEBS Lett. 2014 Mar 18;588(6):929-35. doi: 10.1016/j.febslet.2014.01.050. Epub 2014 Feb 11.
DNA damage sensing by the ATM and ATR kinases.
Maréchal A, Zou L.
Cold Spring Harb Perspect Biol. 2013 Sep 1;5(9). pii: a012716. doi: 10.1101/cshperspect.a012716. Review.
ATM and ATR as therapeutic targets in cancer.
Weber AM, Ryan AJ.
Pharmacol Ther. 2015 May;149:124-38. doi: 10.1016/j.pharmthera.2014.12.001. Epub 2014 Dec 13. Review.
Exclusion/confirmation of ataxia-telangiectasia via cell-cycle testing.
Heinrich T, Prowald C, Friedl R, Gottwald B, Kalb R, Neveling K, Herterich S, Hoehn H, Schindler D.
Eur J Pediatr. 2006 Apr;165(4):250-7. Epub 2006 Jan 13.

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Pathways

ATM Pathway

Description:

References:

ATM kinase promotes both caspase-8 and caspase-9 activation during TNF-a-induced apoptosis of HeLa cells.

DNA damage sensing by the ATM and ATR kinases.

ATM and ATR as therapeutic targets in cancer.

Exclusion/confirmation of ataxia-telangiectasia via cell-cycle testing.

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Tools

Institutional License

Pathways

ATM Pathway

Description:

References:

ATM kinase promotes both caspase-8 and caspase-9 activation during TNF-a-induced apoptosis of HeLa cells.

DNA damage sensing by the ATM and ATR kinases.

ATM and ATR as therapeutic targets in cancer.

Exclusion/confirmation of ataxia-telangiectasia via cell-cycle testing.

Databases

Tools

Institutional License

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