Pathways
Autoimmune Mechanism Causing Vitiligo
Description:
Vitiligo is an acquired autoimmune skin disorder characterized by the destruction of skin melanocytes, resulting in the development of white patches. This disease can be psychologically devastating for the patients. It affects all races and occurs in 0.3–1.0% of the world population, and in 50% of cases the condition begins before the age of 20 years. More women than men are referred with Vitiligo, although the incidence of the disorder is not believed to be sex-linked. Several hypotheses have been proposed rega...
References:
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Perspectives of New Advances in the Pathogenesis of Vitiligo: From Oxidative Stress to Autoimmunity.
Med Sci Monit. 2019 Feb 6;25:1017-1023. doi: 10.12659/MSM.914898. -
Vitiligo: Focus on Clinical Aspects, Immunopathogenesis, and Therapy.
Clin Rev Allergy Immunol. 2018 Feb;54(1):52-67. doi: 10.1007/s12016-017-8622-7. Review. -
Understanding autoimmunity of vitiligo and alopecia areata.
Curr Opin Pediatr. 2016 Aug;28(4):463-9. doi: 10.1097/MOP.0000000000000375. Review. -
Innate immune mechanisms in vitiligo: danger from within.
Curr Opin Immunol. 2013 Dec;25(6):676-82. doi: 10.1016/j.coi.2013.10.010. Epub 2013 Nov 12. Review.
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